以色列大型研究明确孕期常用止痛药安全性，或推动临床指南更新
一项基于逾26万例妊娠的回顾性队列研究显示，布洛芬等非甾体抗炎药在孕早期使用不增加主要先天畸形风险，对乙酰氨基酚全孕期使用同样安全。
一项来自以色列本-古里安大学的研究为孕期止痛药使用提供了迄今最明确的安全性数据。该研究分析了1998年至2018年间索罗卡大学医学中心记录的264,000余例妊娠结局，结果显示，孕早期使用布洛芬等非甾体抗炎药（NSAIDs）与胎儿主要器官系统的先天畸形风险上升无独立关联，对乙酰氨基酚（扑热息痛）在整个孕期使用同样未增加死产、低出生体重或新生儿肾衰竭等不良结局风险。相关论文分别发表于《PLOS Medicine》与《Human Reproduction Open》。
研究负责人、儿科与流行病学专家沙伦·丹尼尔指出，原始数据中暴露组畸形率略高（8.2%对7.0%），但这一差异在调整母体发热、感染、慢性病等混杂因素后完全消失。这意味着真正构成风险的是孕妇潜在的感染或炎症状态，而非药物本身。NSAIDs通过抑制环氧合酶减少前列腺素生成，直接针对疼痛与炎症的源头；对乙酰氨基酚则主要在中枢神经系统层面降低痛觉信号。这一机制差异也解释了为何在月经痛管理中，印尼一项覆盖逾300万消费者的超市交易分析发现，扑热息痛虽为最常购买的经期止痛药，但临床证据表明布洛芬等NSAIDs的镇痛效果更为显著。
该发现与当前女性健康领域对循证依据的迫切需求形成呼应。在社交媒体上，肌醇等膳食补充剂因被宣称可改善激素性痤疮或多囊卵巢综合征而受到追捧，但相关证据多停留于个案经验与小型研究。北美与欧洲的皮肤科及妇科医生观察到，患者对激素管理的认知显著提升，但信息环境混杂，常将相关性与因果性混淆。以色列研究以大规模真实世界数据澄清了孕期用药的核心疑虑，为临床决策提供了更坚实的参照。
研究团队表示，结果支持在医学指征明确时积极处理母体原发疾病，而非因担忧药物风险而回避治疗。下一步，国际妇产科学界是否会据此修订孕期用药指南，以及针对其他NSAIDs品种和儿童远期发育的随访研究，将成为观察重点。
| 欧洲大陆媒体 | −0.20 | neutral |
|---|---|---|
| 以色列媒体 | +0.30 | aligned |
| 拉丁美洲媒体 | −0.50 | critical |
Europe watches with concern as the US and Iran trade blows, but acknowledges the legitimacy of the American response to the drone attack.
The liveblog format creates a sense of immediacy and equivalence, framing the conflict as a symmetrical escalation where each side's actions are presented as reactions to the other's.
The bloc omits the specific details of the Iranian drone attack on the tanker that triggered the US strikes, focusing instead on the US response and Vance's statement.
Israel supports the American operations and insists on the disarmament of Iranian-backed militias in Lebanon and elsewhere.
The bloc uses a hierarchy of threats, placing Iran as the primary source of instability and framing US actions as defensive measures within a broader strategic context.
The bloc omits any mention of civilian casualties from the US strikes or the potential for the escalation to undermine the peace process with Iran.
Iran has the right to defend itself against US bombing, and the peace deal is at risk because of American aggression.
The bloc employs a victimization narrative, presenting Iran as the target of unprovoked US attacks and framing its response as self-defense, while omitting the initial Iranian drone strike.
The bloc omits the fact that the US strikes were a response to an Iranian drone attack on a tanker in the Strait of Hormuz, instead presenting the US as the aggressor.